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http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/10080| Title: | Comparative analysis of sulfated l-idose and l-iduronic acid in neoproteoglycan cell surface engineering |
| Authors: | RAIGAWALI, RAKESH ANAND, SAURABH CHANDRA, ANKITA MAHIDA, VIRENDRASINH BHOGE, PREETI RAVINDRA ABRAHAM, JANCY NIXON KIKKERI, RAGHAVENDRA Dept. of Biology |
| Keywords: | Heparan-Sulfate Antithrombin Activation Binding 2025-MAY-WEEK3 TOC-MAY-2025 2025 |
| Issue Date: | May-2025 |
| Publisher: | Royal Society of Chemistry |
| Citation: | Chemical Communications |
| Abstract: | Herein, we report the synthesis of heparan sulfate (HS) proteoglycan mimetics bearing iduronic acid (IdoA) and sulfated L-idose (Ido) hexasaccharides to assess how these isostructural sugars with similar charge density influence neoproteoglycan display on the cell membrane. PG@I2, carrying sulfated L-idose, showed rapid internalization in both cancerous and normal cells, whereas PG@I1, containing native IdoA expressed on the cell membrane and slowly internalized, underscoring the role of IdoA in HSPG cell surface engineering. |
| URI: | https://doi.org/10.1039/D5CC00527B http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/10080 |
| ISSN: | 1359-7345 1364-548X |
| Appears in Collections: | JOURNAL ARTICLES |
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