Please use this identifier to cite or link to this item: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/10306
Title: An esterase-sensitive persulfide/hydrogen sulfide generating fluorogenic probe enhances antioxidant response
Authors: CHOUDHARY, BHARAT S.
Vashistha, Akshi
Ghosh, Ankan
Agarwal, Rachit
CHAKRAPANI, HARINATH
Dept. of Chemistry
Keywords: Mercaptopyruvate Sulfurtransferase
2025-JUL-WEEK3
TOC-JUL-2025
2025
Issue Date: Jun-2025
Publisher: Royal Society of Chemistry
Citation: Chemical Communications.
Abstract: Hydrogen sulfide (H2S) and sulfane sulfur species such as persulfides and polysulfides protect the cells from oxidative stress and are central to the endogenous antioxidant response. Here, we designed and developed a tool that is cleaved by esterase to generate phenacylthiol, which is an artificial substrate for 3-mercaptopyruvate sulfurtransferase (3-MST) and non-electrophilic lactone as a by-product. The esterase-sensitive persulfide generator enhances H2S and sulfane sulfur and protects chondrocytes from the lethality induced by elevated reactive oxygen species (ROS).
URI: https://doi.org/10.1039/D5CC01523E
http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/10306
ISSN: 1359-7345
1364-548X
Appears in Collections:JOURNAL ARTICLES

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