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Title: Design synthesis and biological evaluation of JNK1 inhibitors
Authors: Venkata Palle
Dept. of Chemistry
Keywords: 2011
Medicinal Chemistry
Issue Date: Apr-2011
Publisher: IISER Pune
Abstract: c-Jun NH2-terminal kinase (JNK) is a stress activated protein kinase which modulate cellular signaling that is implicated in a variety of diseases like type-2 diabetes, cancer, atherosclerosis, stroke, Alzheimer’s and Parkinson diseases. JNK Interacting Protein 1 (JIP1) is a scaffolding protein of JNK which enhances JNK signaling by integrating the modules of JNK signaling. A part of the scaffolding protein- JIP-1 containing 153- 163 AA residues - known as pepJIP1 acts as an inhibitor to JNK at an allosteric site. The present work aims in design, synthesis and biological activity of small molecule allosteric inhibitors of JNK1.
Appears in Collections:MS THESES

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