Please use this identifier to cite or link to this item:
http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/1485| Title: | Glycosylated PROLI/NO Derivatives as Nitric Oxide Prodrugs |
| Authors: | Nandurdikar, Rahul S. Maciag, Anna E. Hong, Sam Y. CHAKRAPANI, HARINATH Citro, Michael L. Keefer, Larry K. Saavedra, Joseph E. Dept. of Chemistry |
| Keywords: | PROLI/NO lysine methyl Glycosidase Peptide residue 2010 |
| Issue Date: | Dec-2009 |
| Publisher: | American Chemical Society |
| Citation: | Organic Letters, 12(1), 56-59. |
| Abstract: | GlcNAc-PROLI/NO prodrugs that are activated by N-acetylglucosaminidase to release nitric oxide (NO) are described. A classical acid-amine coupling is used to bifunctionalize these PROLI/NO prodrugs, which on activation generate up to 4 mol of NO, a peptide residue, and an N-acetylglucosamine residue. Many of the prodrugs synthesized are efficient sources of intracellular NO. |
| URI: | http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/1485 https://doi.org/10.1021/ol902481s |
| ISSN: | 1523-7060 1523-7052 |
| Appears in Collections: | JOURNAL ARTICLES |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.