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http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/1489| Title: | In situ, on-resin synthesis of 8-Br/NH2 adeninyl peptide nucleic acid (PNA) oligomers and complementation studies with DNA |
| Authors: | Vysabhattar, Raman GANESH, KRISHNA N. Dept. of Chemistry |
| Keywords: | Peptide nucleic acid Medicinal chemistry DNA and RNA Pyrimidine PNA sequence Trifluoromethane sulphonic acid 2010 |
| Issue Date: | Dec-2010 |
| Publisher: | Elsevier B.V. |
| Citation: | Tetrahedron Letters, Vol. 50(51). |
| Abstract: | A new, novel and efficient in situ synthesis of 8-aminoadeninyl PNA oligomers from corresponding 8-bromoadeninyl PNA oligomers is reported. The study of hybridisation properties of (8-Br/8-NH2) PNA oligomers with cDNA reveals substitution-site dependent stabilization of derived triplexes and duplexes. |
| URI: | http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/1489 https://doi.org/10.1016/j.tetlet.2010.10.040 |
| ISSN: | 0040-4039 |
| Appears in Collections: | JOURNAL ARTICLES |
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