Please use this identifier to cite or link to this item: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/1493
Title: Tin(ii) chloride assisted synthesis of N-protected γ-amino β-keto esters through semipinacol rearrangement
Authors: BANDYOPADHYAY, ANUPAM
Agrawal, Neha
MALI, SACHITANAND M.
JADHAV, SANDIP V.
GOPI, HOSAHUDYA N.
Dept. of Chemistry
Keywords: chloride
amino aldehydes
2010
Issue Date: Nov-2010
Publisher: Royal Society of Chemistry
Citation: Organic and Biomolecular Chemistry, (21).
Abstract: A facile synthetic route for the preparation of N-protected γ-amino β-keto esters from amino aldehydes and ethyl diazoacetate is described. The two component coupling is facilitated by tin(II) chloride followed by semipinacol rearrangement leading to the product in quantitative yield. The reaction is mild, instantaneous and compatible with Boc-, Fmoc- and Cbz-amino protecting groups.
URI: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/1493
https://doi.org/10.1039/C0OB00199F
ISSN: 1477-0520
1477-0539
Appears in Collections:JOURNAL ARTICLES

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