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Title: | Tin(ii) chloride assisted synthesis of N-protected γ-amino β-keto esters through semipinacol rearrangement |
Authors: | BANDYOPADHYAY, ANUPAM Agrawal, Neha MALI, SACHITANAND M. JADHAV, SANDIP V. GOPI, HOSAHUDYA N. Dept. of Chemistry |
Keywords: | chloride amino aldehydes 2010 |
Issue Date: | Nov-2010 |
Publisher: | Royal Society of Chemistry |
Citation: | Organic and Biomolecular Chemistry, (21). |
Abstract: | A facile synthetic route for the preparation of N-protected γ-amino β-keto esters from amino aldehydes and ethyl diazoacetate is described. The two component coupling is facilitated by tin(II) chloride followed by semipinacol rearrangement leading to the product in quantitative yield. The reaction is mild, instantaneous and compatible with Boc-, Fmoc- and Cbz-amino protecting groups. |
URI: | http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/1493 https://doi.org/10.1039/C0OB00199F |
ISSN: | 1477-0520 1477-0539 |
Appears in Collections: | JOURNAL ARTICLES |
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