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dc.contributor.authorWatve, Mukta M.en_US
dc.contributor.authorDAHANUKAR, NEELESHen_US
dc.contributor.authorWATVE, MILINDen_US
dc.date.accessioned2019-01-21T10:29:58Z
dc.date.available2019-01-21T10:29:58Z
dc.date.issued2010-02en_US
dc.identifier.citationPLoS ONE, 5(2).en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/1512-
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0009328en_US
dc.description.abstractAll genes critical for plasmid replication regulation are located on the plasmid rather than on the host chromosome. It is possible therefore that there can be copy-up “cheater†mutants. In spite of this possibility, low copy number plasmids appear to exist stably in host populations. We examined this paradox using a multilevel selection model. Simulations showed that, a slightly higher copy number mutant could out-compete the wild type. Consequently, another mutant with still higher copy number could invade the first invader. However, the realized benefit of increasing intra-host fitness was saturating whereas that of inter-host fitness was exponential. As a result, above a threshold, intra-host selection was overcompensated by inter-host selection and the low copy number wild type plasmid could back invade a very high copy number plasmid. This led to a rock-paper-scissor (RPS) like situation that allowed the coexistence of plasmids with varied copy numbers. Furthermore, another type of cheater that had lost the genes required for conjugation but could hitchhike on a conjugal plasmid, could further reduce the advantage of copy-up mutants. These sociobiological interactions may compliment molecular mechanisms of replication regulation in stabilizing the copy numbers.en_US
dc.language.isoenen_US
dc.publisherPublic Library Scienceen_US
dc.subjectDNA in bacteriaen_US
dc.subjectSociobiological interactionsen_US
dc.subjectMechanisms of replicationen_US
dc.subject2010en_US
dc.titleSociobiological Control of Plasmid Copy Number in Bacteriaen_US
dc.typeArticleen_US
dc.contributor.departmentDept. of Biologyen_US
dc.identifier.sourcetitlePLoS ONEen_US
dc.publication.originofpublisherForeignen_US
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