Please use this identifier to cite or link to this item: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/1551
Title: Highly Sensitive Coumarin-Pyrazolone Probe for the Detection of Cr3+and the Application in Living Cells
Authors: RAVIKUMAR, GOVINDAN
Mani, Kailasam Saravana et al.
Dept. of Chemistry
Keywords: Fluorescent-Probe
Chemosensor
CR(VI)
Sensor;Chromium(VI)
Conversion
Membrane
TOC-JAN-2019
2018
Issue Date: Dec-2018
Publisher: American Chemical Society
Citation: ACS Omega, Vol. 3(12) pp17212-17219.
Abstract: 3-(7-(Diethylamino)-2-oxo-2H-chromen-3-yl)-1-(4-phenylthiazol-2-yl)-1H-pyrazol-5(4H)-one (COPYR) was competently synthesized from methyl 3-(7-(diethylamino)- 2-oxo-2H-chromen-3-yl)-3-oxopropanoate and 2-hydrazino- 4-phenyl thiazole. The interactions of receptor COPYR with various ions were investigated through absorption and steady-state fluorescence spectral studies, respectively. The results reveal that the complexation of Cr3+ ions with COPYR results in 1:1 stoichiometry, which resulted in a quick color response from fluorescent green to colorless with significant quenching of fluorescence at 506 nm in dimethyl sulfoxide medium. Theoretical calculations (density functional theory) confirm the photophysical changes such as absorbance and emission spectral changes. Furthermore, the confocal imaging of A-549 cells clearly points out that the synthesized probe COPYR could be applied for detecting Cr3+ in living cells.
URI: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/1551
https://doi.org/10.1021/acsomega.8b01907
ISSN: 2470-1343
Appears in Collections:JOURNAL ARTICLES

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