Design and Synthesis of Small Molecule Chloride Receptors for Selective Transmembrane Transport Activity

Abstract

The objective of the thesis is to develop synthetic molecules capable of recognizing anions and transport them across the phospholipid membranes. In all genre of life, ion transporters play vital roles. Naturally occurring ion transporters have broad biological applications as antibiotics, antimalarial agents. The recent progress in the arena of ion transport research has opened up the use of natural and synthetic ion transporters as anticancer agents. The thesis work was performed to evaluate the behavior of certain small organic molecules as anion receptors by 1H NMR titration method, their ion transport activity across the phospholipid membranes, and further the understanding of the mechanism by which these molecule transport ions across vesicular membranes.