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http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/1581| Title: | Novel self-assembled lithocholic acid nanoparticles for drug delivery in cancer |
| Authors: | Patil, Sumersing PATIL, SOHAN Gawali, Suhas Shende, Shrikant Jadhav, Shraddha BASU, SUDIPTA Dept. of Chemistry |
| Keywords: | Lithocholic acid Nanoparticles for drug Cancer cells Cytotoxic drugs Acidic pH 2013 |
| Issue Date: | Aug-2013 |
| Publisher: | Royal Society of Chemistry |
| Citation: | RSC Advances, 3(43), 19760-19764. |
| Abstract: | Novel versatile self-assembled nanoparticles were developed from biocompatible, biodegradable lithocholic acid derivatives. These nanoparticles can incorporate different cytotoxic drugs (paclitaxel and doxorubicin) and PI3K signalling inhibitor (PI103). Drugs were released from the nanoparticles in a slow, sustained manner at acidic pH. The drug loaded nanoparticles were internalized through lysosomal compartments and induced cell death in HeLa cervical cancer cells. |
| URI: | http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/1581 https://doi.org/10.1039/C3RA42994F |
| ISSN: | 2046-2069 |
| Appears in Collections: | JOURNAL ARTICLES |
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