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Please use this identifier to cite or link to this item: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/1587
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dc.contributor.authorSharma, Kavitaen_US
dc.contributor.authorIyer, Aishwaryaen_US
dc.contributor.authorSENGUPTA, KUNDANen_US
dc.contributor.authorCHAKRAPANI, HARINATHen_US
dc.date.accessioned2019-02-14T05:00:09Z
dc.date.available2019-02-14T05:00:09Z
dc.date.issued2013-06en_US
dc.identifier.citationOrganic Letters, 15(11), 2636-2639.en_US
dc.identifier.issn1523-7060en_US
dc.identifier.issn1523-7052en_US
dc.identifier.urihttp://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/1587-
dc.identifier.urihttps://doi.org/10.1021/ol400884ven_US
dc.description.abstractThe design, synthesis, and development of INDQ/NO, a novel nitric oxide (NO) prodrug targeted by a bioreductive trigger, are described. INDQ/NO, an indolequinone-diazeniumdiolate is found to be metabolized to produce NO by DT-diaphorase, a bioreductive enzyme that is overexpressed in certain cancers and hypoxic tumors. Cell-based assays revealed that INDQ/NO induces DNA damage and is a potent inhibitor of cancer cell proliferation.en_US
dc.language.isoenen_US
dc.publisherAmerican Chemical Societyen_US
dc.subjectINDQ/NOen_US
dc.subjectBioreductivelyen_US
dc.subjectNitric Oxide Prodrugen_US
dc.subjectTumoristatic agenten_US
dc.subjectTwo-electron reductaseen_US
dc.subjectReactive nitrogenen_US
dc.subject2013en_US
dc.titleINDQ/NO, a Bioreductively Activated Nitric Oxide Prodrugen_US
dc.typeArticleen_US
dc.contributor.departmentDept. of Chemistryen_US
dc.identifier.sourcetitleOrganic Lettersen_US
dc.publication.originofpublisherForeignen_US
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