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http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/1587| Title: | INDQ/NO, a Bioreductively Activated Nitric Oxide Prodrug |
| Authors: | Sharma, Kavita Iyer, Aishwarya SENGUPTA, KUNDAN CHAKRAPANI, HARINATH Dept. of Chemistry |
| Keywords: | INDQ/NO Bioreductively Nitric Oxide Prodrug Tumoristatic agent Two-electron reductase Reactive nitrogen 2013 |
| Issue Date: | Jun-2013 |
| Publisher: | American Chemical Society |
| Citation: | Organic Letters, 15(11), 2636-2639. |
| Abstract: | The design, synthesis, and development of INDQ/NO, a novel nitric oxide (NO) prodrug targeted by a bioreductive trigger, are described. INDQ/NO, an indolequinone-diazeniumdiolate is found to be metabolized to produce NO by DT-diaphorase, a bioreductive enzyme that is overexpressed in certain cancers and hypoxic tumors. Cell-based assays revealed that INDQ/NO induces DNA damage and is a potent inhibitor of cancer cell proliferation. |
| URI: | http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/1587 https://doi.org/10.1021/ol400884v |
| ISSN: | 1523-7060 1523-7052 |
| Appears in Collections: | JOURNAL ARTICLES |
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