Please use this identifier to cite or link to this item: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/1598
Title: Synthesis and Self-assembly of Amphiphilic Homoglycopolypeptide
Authors: Dhaware, Vinita
Shaikh, Ashif Y.
Kar, Mrityunjoy
HOTHA, SRINIVAS
Sen Gupta, Sayam
Dept. of Chemistry
Keywords: Amphiphilic
Homoglycopolypeptide
Polymerization
Carbohydrates
Glycopolypeptides
2013
Issue Date: May-2013
Publisher: American Chemical Society
Citation: Langmuir, 29(19), 5659-5667.
Abstract: The synthesis of the amphiphilic homoglycopolypeptide was carried out by a combination of NCA polymerization and click chemistry to yield a well-defined polypeptide having an amphiphilic carbohydrate on its side chain. The amphiphilicity of the carbohydrate was achieved by incorporation of an alkyl chain at the C-6 position of the carbohydrate thus also rendering the homoglycopolypeptide amphiphilic. The homoglycopolypeptide formed multimicellar aggregates in water above a critical concentration of 0.9 -M due to phase separation. The multimicellar aggregates were characterized by DLS, TEM, and AFM. It is proposed that hydrophobic interactions of the aliphatic chains at the 6-position of the sugar moieties drives the assembly of these rod-like homoglycopolypeptide into large spherical aggregates. These multimicellar aggregates encapsulate both hydrophilic as well as hydrophobic dye as was confirmed by confocal microscopy. Finally, amphiphilic random polypeptides containing 10% and 20% --d-mannose in addition to glucose containing a hydrophobic alkyl chain at its 6 position were synthesized by our methodology, and these polymers were also found to assemble into spherical nanostructures. The spherical assemblies of amphiphilic random glycopolypeptides containing 10% and 20% mannose were found to be surface bioactive and were found to interact with the lectin Con-A.
URI: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/1598
https://doi.org/10.1021/la400144t
ISSN: 0743-7463
1520-5827
Appears in Collections:JOURNAL ARTICLES

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