PNAs grafted with (α/γ, R/S)-aminomethylene pendants: Regio and stereo specific effects on DNA binding and improved cell uptake

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Title:	PNAs grafted with (α/γ, R/S)-aminomethylene pendants: Regio and stereo specific effects on DNA binding and improved cell uptake
Authors:	Mitrab, Roopa GANESH, KRISHNA N. Dept. of Chemistry
Keywords:	PNAs grafted DNA binding Stereochemistry ethylenediamine 2011
Issue Date:	Jan-2011
Publisher:	Royal Society of Chemistry
Citation:	Chemical Communications, .47 (4), 1198-1200.
Abstract:	PNAs grafted with cationic aminomethylene (am) pendants on the backbone at the glycyl (α) or ethylenediamine (γ) segments show regio (α/γ) and stereochemistry (R/S) dependent binding with complementary DNA. These are efficiently taken up by cells, with γ(S-am)aeg-PNA being the best in all properties.
URI:	http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/1757 https://doi.org/10.1039/C0CC03988H
ISSN:	1359-7345 1364-548X
Appears in Collections:	JOURNAL ARTICLES

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