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http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/1927| Title: | Arylboronate Ester Based Diazeniumdiolates (BORO/NO), a Class of Hydrogen Peroxide Inducible Nitric Oxide (NO) Donors |
| Authors: | DHARMARAJA, ALLIMUTHU T. RAVIKUMAR, GOVINDAN CHAKRAPANI, HARINATH Dept. of Chemistry |
| Keywords: | Arylboronate Ester Diazeniumdiolates Hydrogen Peroxide Evaluation of arylboronate Biological studies Boronate ester protecting groups 2014 |
| Issue Date: | May-2014 |
| Publisher: | American Chemical Society |
| Citation: | Organic Letters, 16(10), 2610-2613. |
| Abstract: | Here, we report the design, synthesis, and evaluation of arylboronate ester based diazeniumdiolates (BORO/NO), a class of nitric oxide (NO) donors activated by hydrogen peroxide (H2O2), a reactive oxygen species (ROS), to generate NO. We provide evidence for the NO donors’ ability to permeate bacteria to produce NO when exposed to H2O2 supporting possible applications for BORO/NO to study molecular mechanisms of NO generation in response to elevated ROS. |
| URI: | http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/1927 https://doi.org/10.1021/ol5010643 |
| ISSN: | 1523-7060 1523-7052 |
| Appears in Collections: | JOURNAL ARTICLES |
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