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http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/1928| Title: | A Small Molecule for Controlled Generation of Reactive Oxygen Species (ROS) |
| Authors: | DHARMARAJA, ALLIMUTHU T. CHAKRAPANI, HARINATH Dept. of Chemistry |
| Keywords: | Small Molecule Controlled Generation Oxygen Species Bacteria to increased ROS 2014 |
| Issue Date: | Jan-2014 |
| Publisher: | American Chemical Society |
| Citation: | Organic Letters, 16(2), 398-401. |
| Abstract: | Due to the short half-life of reactive oxygen species (ROS) such as a superoxide radical, controlled and localized generation of ROS is challenging. Here, we report a rationally designed small-molecule 1c that generates ROS only when triggered by a bacterial enzyme. We provide evidence for 1c predictably enhancing the intracellular superoxide radical in a model bacterium. Spatiotemporal control over ROS generation offered by 1c should help better understand stress responses in bacteria to increased ROS. |
| URI: | http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/1928 https://doi.org/10.1021/ol403300a |
| ISSN: | 1523-7060 1523-7052 |
| Appears in Collections: | JOURNAL ARTICLES |
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