Clickable Cγ-Azido(methylene/butylene) Peptide Nucleic Acids and Their Clicked Fluorescent Derivatives: Synthesis, DNA Hybridization Properties, and Cell Penetration Studies

Please use this identifier to cite or link to this item: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/1930

Title:	Clickable Cγ-Azido(methylene/butylene) Peptide Nucleic Acids and Their Clicked Fluorescent Derivatives: Synthesis, DNA Hybridization Properties, and Cell Penetration Studies
Authors:	Jain, Deepak R. GANESH, KRISHNA N. Dept. of Chemistry
Keywords:	Fluorescent Derivatives Peptide Nucleic Acid DNA Hybridization Cell Penetration Studies Carboxyfluorescein Nuclear membrane 2014
Issue Date:	Jul-2014
Publisher:	American Chemical Society
Citation:	Journal of Organic Chemistry, 79(14), 6708-6714.
Abstract:	Synthesis, characterization, and DNA complementation studies of clickable Cγ-substituted methylene (azm)/butylene (azb) azido PNAs show that these analogues enhance the stability of the derived PNA:DNA duplexes. The fluorescent PNA oligomers synthesized by their click reaction with propyne carboxyfluorescein are seen to accumulate around the nuclear membrane in 3T3 cells.
URI:	http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/1930 https://doi.org/10.1021/jo500834u
ISSN:	0022-3263 1520-6904
Appears in Collections:	JOURNAL ARTICLES

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