Please use this identifier to cite or link to this item: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/2016
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dc.contributor.authorGujarati, Tanvi P.en_US
dc.contributor.authorAMBIKA, G.en_US
dc.date.accessioned2019-02-25T09:03:15Z
dc.date.available2019-02-25T09:03:15Z
dc.date.issued2014-12en_US
dc.identifier.citationJournal of Mathematical Biology, 69(6-7), 1773-1800.en_US
dc.identifier.issn0303-6812en_US
dc.identifier.issn1432-1416en_US
dc.identifier.urihttp://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/2016-
dc.identifier.urihttps://doi.org/110.1007/s00285-013-0749-4en_US
dc.description.abstractDengue viral infections show unique infection patterns arising from its four serotypes, (DENV-1,2,3,4). Its effects range from simple fever in primary infections to potentially fatal secondary infections. We analytically and numerically analyse virus dynamics and humoral response in a host during primary and secondary dengue infection for long periods using micro-epidemic models. The models presented here incorporate time delays, antibody dependent enhancement, a dynamic switch and a correlation factor between different DENV serotypes. We find that the viral load goes down to undetectable levels within 7–14 days as is observed for dengue infection, in both cases. For primary infection, the stability analysis of steady states shows interesting dependence on the time delay involved in the production of antibodies from plasma cells. We demonstrate the existence of a critical value for the immune response parameter, beyond which the infection gets completely cured. For secondary infections with a different serotype, the homologous antibody production is enhanced due to the influence of heterologous antibodies. The antibody production is also controlled by the correlation factor, which is a measure of similarities between the different DENV serotypes involved. Our results agree with clinically observed humoral responses for primary and secondary infections.en_US
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.subjectVirus antibody dynamicsen_US
dc.subjectDengue infectionsen_US
dc.subjectVirus dynamicsen_US
dc.subjectHumoral immune responseen_US
dc.subjectAntibody dependent enhancementen_US
dc.subjectCorrelation factor among serotypesen_US
dc.subjectTime delayen_US
dc.subjectStability analysisen_US
dc.subject2014en_US
dc.titleVirus antibody dynamics in primary and secondary dengue infectionsen_US
dc.typeArticleen_US
dc.contributor.departmentDept. of Physicsen_US
dc.identifier.sourcetitleJournal of Mathematical Biologyen_US
dc.publication.originofpublisherForeignen_US
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