Novel tetra-peptide insertion in Gag-p6 ALIX-binding motif in HIV-1 subtype C associated with protease inhibitor failure in Indian patients.

Please use this identifier to cite or link to this item: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/2065

Title:	Novel tetra-peptide insertion in Gag-p6 ALIX-binding motif in HIV-1 subtype C associated with protease inhibitor failure in Indian patients.
Authors:	Ujjwal Neogi Shwetha Rao Irene Bontell Jens Verheyen Vasudev Rao Sagar Gore Neelesh Soni Anita Shet Eugen Schlter Maria Ekstrand Amogne Wondwossen Rolf Kaiser MADHUSUDHAN, M. S. Vinayaka Prasad Anders Sonnerborg Dept. of Biology
Keywords:	Novel tetra-peptide HIV-1 subtype Indian patients Protease inhibitor drugs 2014
Issue Date:	Sep-2014
Publisher:	Lippincott, Williams & Wilkins
Citation:	AIDS, 28(15),2319 2322.
Abstract:	A novel tetra-peptide insertion was identified in Gag-p6 ALIX-binding region, which appeared in protease inhibitor failure Indian HIV-1C sequences (odds ratio=17.1, P < 0.001) but was naturally present in half of untreated Ethiopian HIV-1C sequences. The insertion is predicted to restore ALIX-mediated virus release pathway, which is lacking in HIV-1C. The clinical importance of the insertion needs to be evaluated in HIV-1C dominating regions wherein the use of protease inhibitor drugs are being scaled up.
URI:	http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/2065 https://doi.org/10.1097/QAD.0000000000000419
ISSN:	2319 2322 1473-5571
Appears in Collections:	JOURNAL ARTICLES

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