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dc.contributor.authorUjjwal Neogien_US
dc.contributor.authorShwetha Raoen_US
dc.contributor.authorIrene Bontellen_US
dc.contributor.authorJens Verheyenen_US
dc.contributor.authorVasudev Raoen_US
dc.contributor.authorSagar Goreen_US
dc.contributor.authorNeelesh Sonien_US
dc.contributor.authorAnita Sheten_US
dc.contributor.authorEugen Schlteren_US
dc.contributor.authorMaria Ekstranden_US
dc.contributor.authorAmogne Wondwossenen_US
dc.contributor.authorRolf Kaiseren_US
dc.contributor.authorMADHUSUDHAN, M. S.en_US
dc.contributor.authorVinayaka Prasaden_US
dc.contributor.authorAnders Sonnerborgen_US
dc.date.accessioned2019-02-25T09:04:43Z
dc.date.available2019-02-25T09:04:43Z
dc.date.issued2014-09en_US
dc.identifier.citationAIDS, 28(15),2319 2322.en_US
dc.identifier.issn2319 2322en_US
dc.identifier.issn1473-5571en_US
dc.identifier.urihttp://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/2065-
dc.identifier.urihttps://doi.org/10.1097/QAD.0000000000000419en_US
dc.description.abstractA novel tetra-peptide insertion was identified in Gag-p6 ALIX-binding region, which appeared in protease inhibitor failure Indian HIV-1C sequences (odds ratio=17.1, P < 0.001) but was naturally present in half of untreated Ethiopian HIV-1C sequences. The insertion is predicted to restore ALIX-mediated virus release pathway, which is lacking in HIV-1C. The clinical importance of the insertion needs to be evaluated in HIV-1C dominating regions wherein the use of protease inhibitor drugs are being scaled up.en_US
dc.language.isoenen_US
dc.publisherLippincott, Williams & Wilkinsen_US
dc.subjectNovel tetra-peptideen_US
dc.subjectHIV-1 subtypeen_US
dc.subjectIndian patientsen_US
dc.subjectProtease inhibitor drugsen_US
dc.subject2014en_US
dc.titleNovel tetra-peptide insertion in Gag-p6 ALIX-binding motif in HIV-1 subtype C associated with protease inhibitor failure in Indian patients.en_US
dc.typeArticleen_US
dc.contributor.departmentDept. of Biologyen_US
dc.identifier.sourcetitleAIDSen_US
dc.publication.originofpublisherForeignen_US
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