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http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/2139| Title: | A convenient protocol for the deprotection of N-benzyloxycarbonyl (Cbz) and benzyl ester groups |
| Authors: | SULTANE, PRAKASH R. Mete, Trimbak B. BHAT, RAMAKRISHNA G. Dept. of Chemistry |
| Keywords: | Natural products Amino acids Deprotection Hydrogenolysis Practicability 2015 |
| Issue Date: | Apr-2015 |
| Publisher: | Elsevier B.V. |
| Citation: | Tetrahedron Letters, 56(16), 2067-2070. |
| Abstract: | We describe a convenient and practical method for the deprotection of N-benzyloxycarbonyl (Cbz) and benzyl ester groups using NaBH4 and catalytic Pd–C in methanol. Deprotection was very facile and rapid. In situ generation of hydrogen is certainly user friendly and avoids the use of a hydrogen cylinder. In order to establish the wider applicability of this approach, deprotection has also been demonstrated in gram scale reactions |
| URI: | http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/2139 https://doi.org/10.1016/j.tetlet.2015.02.131 |
| ISSN: | 0040-4039 |
| Appears in Collections: | JOURNAL ARTICLES |
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