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http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/2145| Title: | Design of Stable β-Hairpin Mimetics through Backbone Disulfide Bonds |
| Authors: | Kumar, Mothukuri Ganesh MALI, SACHITANAND M. Raja, K. Muruga Poopathi GOPI, HOSAHUDYA N. Dept. of Chemistry |
| Keywords: | Design of Stable β-Hairpin Disulfide Bonds Stable protein secondary structure Antimicrobial peptides 2015 |
| Issue Date: | Jan-2015 |
| Publisher: | American Chemical Society |
| Citation: | Organic Letters, 17 (2), 230-233. |
| Abstract: | The synthesis and utilization of novel thiostatines (β-SH-substituted γ-amino acids) in the design of backbone-disulfide-stabilized β-hairpin mimetics, solution conformations of hybrid β-hairpins and Cys-disulfide-stabilized α-peptide analogue, their thiol exchange, and proteolytic stability are investigated. The results suggest that thiostatines can be used to design proteolytically stable water-soluble β-hairpin mimetics without deviating from overall β-hairpin conformation. |
| URI: | http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/2145 https://doi.org/10.1021/ol503310r |
| ISSN: | 1523-7060 1523-7052 |
| Appears in Collections: | JOURNAL ARTICLES |
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