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http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/2155| Title: | Propargyl 1,2-Orthoesters for a Catalytic and Stereoselective Synthesis of Pyrimidine Nucleosides |
| Authors: | Rao, Boddu Venkateswara Manmode, Sujit HOTHA, SRINIVAS Dept. of Chemistry |
| Keywords: | Catalytic and Stereoselective Catalytic and Stereoselective High-yielding protocol 2015 |
| Issue Date: | Feb-2015 |
| Publisher: | American Chemical Society |
| Citation: | Journal of Organic Chemistry, 80 (3),1499-1505. |
| Abstract: | Pyrimidine nucleosides are synthesized by using propargyl 1,2-orthoesters and Au(III) salt as a catalyst. Strategically positioned 1,2-orthoesters are found to yield only 1,2-trans nucleosides and enable preparation of 2′-OH containing pyrimidine nucleosides. The glycosyl donor employed in this study is stable and easily accessible. The identified high-yielding protocol is mild, diastereoselective, and catalytic. |
| URI: | http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/2155 https://doi.org/10.1021/jo502413z |
| ISSN: | 1499-1505 1520-6904 |
| Appears in Collections: | JOURNAL ARTICLES |
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