Please use this identifier to cite or link to this item: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/2162
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dc.contributor.authorYadav, Rohanen_US
dc.contributor.authorMurthy, Raghavendra Vasudevaen_US
dc.contributor.authorKIKKERI, RAGHAVENDRAen_US
dc.date.accessioned2019-03-15T11:23:08Z
dc.date.available2019-03-15T11:23:08Z
dc.date.issued2015-07en_US
dc.identifier.citationChemBioChem, 16(10), 1448-1453.en_US
dc.identifier.issn1439-4227en_US
dc.identifier.issn1439-7633en_US
dc.identifier.urihttp://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/2162-
dc.identifier.urihttps://doi.org/10.1002/cbic.201500162en_US
dc.description.abstractCurrent methods for Alzheimer's treatment require a three‐component system: metal chelators, antioxidants, and amyloid β (Aβ)‐peptide‐binding scaffolds. We report sialic acid (Sia) hydroxamate as a potential radical scavenger and metal chelator to inhibit Aβ aggregation. A cell viability assay revealed that Sia hydroxamate can protect HeLa and glioblastoma (LN229) cells from oxidative damage induced by the Fenton reaction. Sedimentation and turbidity assays showed profound protection of neuroblastoma SH‐SY5Y cells from metal‐induced Aβ aggregation and neural toxicity.en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.subjectSialic Acid Hydroxamateen_US
dc.subjectPotential Antioxidanten_US
dc.subject??Amyloid Aggregatesen_US
dc.subjectAlzheimer's treatmenten_US
dc.subject2015en_US
dc.titleSialic Acid Hydroxamate: A Potential Antioxidant and Inhibitor of Metal‐Induced β‐Amyloid Aggregatesen_US
dc.typeArticleen_US
dc.contributor.departmentDept. of Chemistryen_US
dc.identifier.sourcetitleChemBioChemen_US
dc.publication.originofpublisherForeignen_US
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