Please use this identifier to cite or link to this item:
http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/2162| Title: | Sialic Acid Hydroxamate: A Potential Antioxidant and Inhibitor of Metal‐Induced β‐Amyloid Aggregates |
| Authors: | Yadav, Rohan Murthy, Raghavendra Vasudeva KIKKERI, RAGHAVENDRA Dept. of Chemistry |
| Keywords: | Sialic Acid Hydroxamate Potential Antioxidant ??Amyloid Aggregates Alzheimer's treatment 2015 |
| Issue Date: | Jul-2015 |
| Publisher: | Wiley |
| Citation: | ChemBioChem, 16(10), 1448-1453. |
| Abstract: | Current methods for Alzheimer's treatment require a three‐component system: metal chelators, antioxidants, and amyloid β (Aβ)‐peptide‐binding scaffolds. We report sialic acid (Sia) hydroxamate as a potential radical scavenger and metal chelator to inhibit Aβ aggregation. A cell viability assay revealed that Sia hydroxamate can protect HeLa and glioblastoma (LN229) cells from oxidative damage induced by the Fenton reaction. Sedimentation and turbidity assays showed profound protection of neuroblastoma SH‐SY5Y cells from metal‐induced Aβ aggregation and neural toxicity. |
| URI: | http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/2162 https://doi.org/10.1002/cbic.201500162 |
| ISSN: | 1439-4227 1439-7633 |
| Appears in Collections: | JOURNAL ARTICLES |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.