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Title: Assessing the effect of different shapes of glyco-gold nanoparticles on bacterial adhesion and infections
Authors: Chaudhary, Preeti Madhukar
Sangabathuni, Sivakoti
Murthy, Raghavendra Vasudeva
Paul, Ajay
Thulasiram, Hirekodathakallu V.
Dept. of Chemistry
Keywords: Glyco-gold nanoparticles
Bacterial adhesion
Issue Date: Aug-2015
Publisher: Royal Society of Chemistry
Citation: Chemical Communications, 51(86),15669-15672.
Abstract: Achieving selective and sensitive carbohydrate-protein interactions (CPIs) using nanotechnology is an intriguing area of research. Here we demonstrate that the different shapes of gold nanoparticles (AuNPs) functionalized with monosaccharides tune the bacterial aggregations. The mechanism of aggregation revealed that the large number of surface interactions of rod shaped mannose-AuNPs with E. coli ORN 178 compared with spherical and star-shaped AuNPs exhibited higher avidity and sensitivity. Moreover, such sensitive binding can be used for effective inhibition of bacterial infection of cells.
ISSN: 1359-7345
Appears in Collections:JOURNAL ARTICLES

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