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Title: Biological Activity of Coumarin Derivatives as Anti-Leishmanial Agents
Authors: Mandlik, Vineetha
Bopanna, Ramanamurthy
Singh, Shailza
Dept. of Chemistry
Keywords: Insilico screening
Biological Activity
Coumarin Derivatives
Anti-Leishmanial Agents
Complementary therapeutic
Issue Date: Oct-2016
Publisher: Public Library Science
Citation: PLoS ONE, 11(10), 0164585.
Abstract: Cutaneous leishmaniasis affects nearly 0.7 to 1.3 million people annually. Treatment of this disease is difficult due to lack of appropriate medication and the growing problem of drug resistance. Natural compounds such as coumarins serve as complementary therapeutic agents in addition to the current treatment modalities. In this study, we have performed an in-silico screening of the coumarin derivatives and their anti-leishmanial properties has been explored both in-vitro and in-vivo. One of the compounds (compound 2) exhibited leishmanicidal activity and to further study its properties, nanoliposomal formulation of the compound was developed. Treatment of cutaneous lesions in BALB/c mice with compound 2 showed significantly reduced lesion size as compared to the untreated mice (p<0.05) suggesting that compound 2 may possess anti-leishmanial properties.
ISSN: 1932-6203
Appears in Collections:JOURNAL ARTICLES

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