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http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/2494| Title: | Perfluoroalkylchain conjugation as a new tactic for enhancing cell permeability of peptide nucleic acids (PNAs) via reducing the nanoparticle size |
| Authors: | Ellipilli, Satheesh Murthy, Raghavendra Vasudeva GANESH, KRISHNA N. Dept. of Chemistry |
| Keywords: | New tactic Cell permeability Peptide nucleic acids Reducing the nanoparticle size Lipids to promote 2016 |
| Issue Date: | Oct-2015 |
| Publisher: | Royal Society of Chemistry |
| Citation: | Chemical Communications, 52(3), 521-524 . |
| Abstract: | Perfluoro undecanoyl chain conjugated peptide nucleic acids (PNAs) show 2.5 to 3 fold higher cellular uptake efficiency in NIH 3T3 and HeLa cells compared to simple undecanoyl PNAs. Fluorination of PNAs leads to the formation of lower size (∼100–250 nm) nanoparticles compared to larger size (∼500 nm) nanoparticles from non-fluorinated PNAs, thereby improving the efficiency of cell penetration. |
| URI: | http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/2494 https://doi.org/10.1039/C5CC05342K |
| ISSN: | 1359-7345 1364-548X |
| Appears in Collections: | JOURNAL ARTICLES |
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