Please use this identifier to cite or link to this item:
http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/2622| Title: | Isolation and Characterization of Bioactive Benzofuran Sesquiterpene from Marine Sponge Ircinia Fusca (Carter, 1880) |
| Authors: | Meesala, Srinu Lakwal, Vijay R. Kharate, Dinesh S. Mokashe, Satish S. WATVE, MILIND Dept. of Biology |
| Keywords: | Sponge Sesquiterpenes NMR & Mass spectrometry Natural Products Antimicrobial anticancer activity Marine organisms 2016 |
| Issue Date: | Aug-2016 |
| Publisher: | JCBPSC |
| Citation: | Journal of Chemical, Biological and Physical Sciences, 6(4), 1400-1418. |
| Abstract: | A novel benzofuran sesquiterpene derivative:7-methyl-7-((E)-4-methylpenta1,3-dien-1-yl)-5,6,7,7a-tetrahydrobenzofuran-3a(4H)-ol(Iricinol A), was isolated from a marine sponge Ircinia fusca (Carter, 1880). The structure of the compound was elucidated by using 1D, 2DNMR, and ESI-MS-TOF. The compound showed broad-spectrum activity against bacteria and fungi at 2 µg/µL. Also, it exhibited in vitro cytotoxic activity against RAW264.7 cells (mouse monotype macrophage leukemia) and N2A cells (neuroblastoma) with IC50 values 55 ± 4.21 µg/mL. |
| URI: | http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/2622 - |
| ISSN: | 2249 -1929 |
| Appears in Collections: | JOURNAL ARTICLES |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.