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Title: Extratropical anticyclonic Rossby wave breaking and Indian summer monsoon failure
Authors: Samanta, Dhrubajyoti
Dash, M. K.
Pandey, P. C.
Dept. of Earth and Climate Science
Keywords: Extratropical anticyclonic
Rossby wave
Indian summer monsoon failure
Mdratitude disturbances
Rossby wave breaking
Indian summer monsoon
Blocking Monsoonal convection
Issue Date: Mar-2016
Publisher: Springer Nature
Citation: Climate Dynamics, 46(5-6), 1547-1562.
Abstract: The global incidence of tuberculosis is increasing at an alarming rate, and Mycobacterium tuberculosis (Mtb) is the causative agent for tuberculosis, a disease with high mortality. Lipoarabinomannan (LAM) is one of the major components of the Mtb cellular envelope and is an attractive scaffold for developing anti-tubercular drugs, vaccines and diagnostics. Herein, a highly convergent strategy is developed to synthesize heneicosasaccharyl arabinomannan for the first time. The arabinomannan synthesized in this endeavour has several 1,2-trans or α-Araf linkages and three 1,2-cis or β-Araf linkages end capped with 1,2-trans or α-Manp linkages. All the key glycosidations were performed with alkynyl carbonate glycosyl donors under [Au]/[Ag] catalysis conditions, which gave excellent yields and stereoselectivity even for the reactions between complex and branched oligosaccharides. The resultant allyl oligosaccharide was globally deprotected to obtain the heneicosasaccharyl arabinomannan as a propyl glycoside. In summary, heneicosasaccharyl mannose capped arabinomannan synthesis was achieved in 56 steps with 0.016% overall yield.
ISSN: 1007-1027
Appears in Collections:JOURNAL ARTICLES

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