Please use this identifier to cite or link to this item:
http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/2646Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Ogura, Yuji | en_US |
| dc.contributor.author | Parsons, William H. | en_US |
| dc.contributor.author | KAMAT, SIDDHESH S. | en_US |
| dc.contributor.author | Cravatt, Benjamin F | en_US |
| dc.date.accessioned | 2019-04-29T09:25:03Z | |
| dc.date.available | 2019-04-29T09:25:03Z | |
| dc.date.issued | 2016-07 | en_US |
| dc.identifier.citation | Nature Chemical Biology, 12(9), 669-671. | en_US |
| dc.identifier.issn | 1552-4450 | en_US |
| dc.identifier.issn | 1552-4469 | en_US |
| dc.identifier.uri | http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/2646 | - |
| dc.identifier.uri | https://doi.org/10.1038/nchembio.2127 | en_US |
| dc.description.abstract | More than 30 years ago, a calcium-dependent enzyme activity was described that generates N-acyl phosphatidylethanolamines (NAPEs), which are precursors for N-acyl ethanolamine (NAE) lipid transmitters, including the endocannabinoid anandamide. The identity of this calcium-dependent N-acyltransferase (Ca-NAT) has remained mysterious. Here, we use activity-based protein profiling to identify the poorly characterized serine hydrolase PLA2G4E as a mouse brain Ca-NAT and show that this enzyme generates NAPEs and NAEs in mammalian cells. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Nature Publishing Group | en_US |
| dc.subject | Calcium-dependent enzyme | en_US |
| dc.subject | N-acyltransferase | en_US |
| dc.subject | NAEs are a class of bioactive lipids | en_US |
| dc.subject | Brain Ca-NAT | en_US |
| dc.subject | PLA2G4E | en_US |
| dc.subject | 2016 | en_US |
| dc.title | A calcium-dependent acyltransferase that produces N-acyl phosphatidylethanolamines | en_US |
| dc.type | Article | en_US |
| dc.contributor.department | Dept. of Biology | en_US |
| dc.identifier.sourcetitle | Nature Chemical Biology | en_US |
| dc.publication.originofpublisher | Foreign | en_US |
| Appears in Collections: | JOURNAL ARTICLES | |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.