Please use this identifier to cite or link to this item:
http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/2646| Title: | A calcium-dependent acyltransferase that produces N-acyl phosphatidylethanolamines |
| Authors: | Ogura, Yuji Parsons, William H. KAMAT, SIDDHESH S. Cravatt, Benjamin F Dept. of Biology |
| Keywords: | Calcium-dependent enzyme N-acyltransferase NAEs are a class of bioactive lipids Brain Ca-NAT PLA2G4E 2016 |
| Issue Date: | Jul-2016 |
| Publisher: | Nature Publishing Group |
| Citation: | Nature Chemical Biology, 12(9), 669-671. |
| Abstract: | More than 30 years ago, a calcium-dependent enzyme activity was described that generates N-acyl phosphatidylethanolamines (NAPEs), which are precursors for N-acyl ethanolamine (NAE) lipid transmitters, including the endocannabinoid anandamide. The identity of this calcium-dependent N-acyltransferase (Ca-NAT) has remained mysterious. Here, we use activity-based protein profiling to identify the poorly characterized serine hydrolase PLA2G4E as a mouse brain Ca-NAT and show that this enzyme generates NAPEs and NAEs in mammalian cells. |
| URI: | http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/2646 https://doi.org/10.1038/nchembio.2127 |
| ISSN: | 1552-4450 1552-4469 |
| Appears in Collections: | JOURNAL ARTICLES |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.