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http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/2662| Title: | Screening of Neu5Acα(2–6)gal isomer preferences of siglecs with a sialic acid microarray |
| Authors: | Yadav, Rohan Ben Arye, Shani Leviatan SUBRAMANI, BALAMURUGAN Padler-Karavani, Vered KIKKERI, RAGHAVENDRA Dept. of Chemistry |
| Keywords: | Screening of Neu5Ac? Sialic acid microarray Glycoproteins Immune responses Tumorigenesis 2016 |
| Issue Date: | Sep-2016 |
| Publisher: | Royal Society of Chemistry |
| Citation: | Organic and Biomolecular Chemistry, 14(46), 10812-10815. |
| Abstract: | Sialic acids (Sias) are important terminal sugars on cell surfaces involved in a wide range of protein–carbohydrate interactions. Hence, agents modulating sias-mediated protein interactions are promising inhibitors or vaccine candidates. Here, we report the synthesis of Neu5Acα(2–6)Gal structural analogs and their binding to a series of siglecs. The results showed distinct binding patterns with conserved siglecs (hCD22 and mCD22) compared to rapid evolving siglecs (Siglecs -3 & -10). |
| URI: | http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/2662 https://doi.org/10.1039/C6OB01688J |
| ISSN: | 1477-0520 1477-0539 |
| Appears in Collections: | JOURNAL ARTICLES |
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