Please use this identifier to cite or link to this item: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/2663
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dc.contributor.authorGADE, MADHURIen_US
dc.contributor.authorKhandelwal, Puneeten_US
dc.contributor.authorSangabathuni, Sivakotien_US
dc.contributor.authorBAVIREDDI, HARIKRISHNAen_US
dc.contributor.authorMurthy, Raghavendra Vasudevaen_US
dc.contributor.authorPoddar, Pankajen_US
dc.contributor.authorKIKKERI, RAGHAVENDRAen_US
dc.date.accessioned2019-04-29T10:14:35Z
dc.date.available2019-04-29T10:14:35Z
dc.date.issued2016-02en_US
dc.identifier.citationAnalyst, 141(7), 2250-2258.en_US
dc.identifier.issnMar-54en_US
dc.identifier.issn1364-5528en_US
dc.identifier.urihttp://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/2663-
dc.identifier.urihttps://doi.org/10.1039/C5AN02336Jen_US
dc.description.abstractThe multivalent display of carbohydrates on the cell surface provides cooperative binding to improve the specific biological events. In addition to multivalency, the spatial arrangement and orientation of sugars with respect to external stimuli also trigger carbohydrate–protein interactions. Herein, we report a non-covalent host–guest strategy to immobilize heptavalent glyco-β-cyclodextrin on gold-coated glass slides to study multivalent carbohydrate–protein interactions. We have found that the localization of sugar entities on surfaces using β-cyclodextrin (β-CD) chemistry increased the avidity of carbohydrate–protein and carbohydrate–macrophage interactions compared to monovalent-β-CD sugar coated surfaces. This platform is expected to be a promising tool to amplify the avidity of sugar-mediated interactions on surfaces and contribute to the development of next generation bio-medical products.en_US
dc.language.isoenen_US
dc.publisherRoyal Society of Chemistryen_US
dc.subjectImmobilization of multivalenten_US
dc.subjectSensing proteinsen_US
dc.subjectMacrophagesen_US
dc.subjectMultivalent displayen_US
dc.subject2016en_US
dc.titleImmobilization of multivalent glycoprobes on gold surfaces for sensing proteins and macrophagesen_US
dc.typeArticleen_US
dc.contributor.departmentDept. of Chemistryen_US
dc.identifier.sourcetitleAnalysten_US
dc.publication.originofpublisherForeignen_US
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