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http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/2670| Title: | A Small Molecule for Controlled Generation of Peroxynitrite |
| Authors: | KHODADE, VINAYAK S. Kulkarni, Apoorva Sen Gupta, Ayantika SENGUPTA, KUNDAN CHAKRAPANI, HARINATH Dept. of Biology |
| Keywords: | Controlled Generation of Peroxynitrite Peroxynitrite Small molecule containing a superoxide Nitric oxide 2016 |
| Issue Date: | Mar-2016 |
| Publisher: | American Chemical Society |
| Citation: | Organic Letters,18 (6), 1274-1277. |
| Abstract: | 2-Methyl-3-[1-(N,N-dimethylamino)diazen-1-ium-1,2-diol-2-ato-methyl]-naphthalene-1,4-dione 1 (HyPR-1), a small molecule containing a superoxide generator strategically linked to a diazeniumdiolate-based nitric oxide donor, is reported. Evidence for HyPR-1’s ability to generate peroxynitrite in the presence of an enzyme as well as enhance peroxynitrite within cells is provided. The utility of this tool in generating peroxynitrite for cellular studies is demonstrated. |
| URI: | http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/2670 https://doi.org/10.1021/acs.orglett.6b00186 |
| ISSN: | 1523-7060 1523-7052 |
| Appears in Collections: | JOURNAL ARTICLES |
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