Transition-metal-free synthesis of primary to tertiary carboxamides: A quick access to prodrug-pyrazinecarboxamide

Please use this identifier to cite or link to this item: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/3198

Title:	Transition-metal-free synthesis of primary to tertiary carboxamides: A quick access to prodrug-pyrazinecarboxamide
Authors:	Mete, Trimbak B. Singh, Ankit BHAT, RAMAKRISHNA G. Dept. of Chemistry
Keywords:	One-pot expedient Transition-metal-free Caboxamide Carbamoylation Potassium persul fate Heteroaromatic 2017
Issue Date:	Dec-2017
Publisher:	Elsevier B.V.
Citation:	Tetrahedron Letters, 58(50), 4709-4712.
Abstract:	One-pot expedient and direct carbamoylation of heterocyclics is described. The transformation is realized via direct dehydrogenative aminocarbonylation of heterocyclic compounds under transition-metal-free conditions. This method is regioselective and the protocol is proved to be scalable on a gram scale. Further, the therapeutically useful antitubercular agent pyrazinecarboxamide is successfully synthesized by employing this protocol.
URI:	http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/3198 https://doi.org/10.1016/j.tetlet.2017.11.006
ISSN:	0040-4039
Appears in Collections:	JOURNAL ARTICLES

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