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http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/3209| Title: | Esterase Activated Carbonyl Sulfide/Hydrogen Sulfide (H2S) Donors |
| Authors: | Chauhan, Preeti BORA, PRERONA RAVIKUMAR, GOVINDAN Jos, Swetha CHAKRAPANI, HARINATH Dept. of Chemistry |
| Keywords: | Esterase Activated Carbonyl Sulfide (H2S) Donors Carbonyl sulfide (COS) H2S donors COS/H2S 2017 |
| Issue Date: | Jan-2017 |
| Publisher: | American Chemical Society |
| Citation: | Organic Letters, 19 (1), 62-65. |
| Abstract: | Hydrogen sulfide (H2S) is a mediator of a number of cellular processes, and modulating cellular levels of this gas has emerged as an important therapeutic area. Localized generation of H2S is thus very useful but highly challenging. Here, we report pivaloyloxymethyl-based carbonothioates and carbamothioates that are activated by the enzyme, esterase, to generate carbonyl sulfide (COS), which is hydrolyzed to H2S. |
| URI: | http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/3209 https://doi.org/10.1021/acs.orglett.6b03336 |
| ISSN: | 1523-7060 1523-7052 |
| Appears in Collections: | JOURNAL ARTICLES |
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