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http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/3210| Title: | A small molecule for theraNOstic targeting of cancer cells |
| Authors: | RAVIKUMAR, GOVINDAN Bagheri, Meisam Saini, Deepak Kumar CHAKRAPANI, HARINATH Dept. of Chemistry |
| Keywords: | Small molecule theraNOstic targeting Cancer cells Cytotoxic effect of compound Fluorophore Fluorescence corresponding 2017 |
| Issue Date: | Nov-2017 |
| Publisher: | Royal Society of Chemistry |
| Citation: | Chemical Communications, 53(61), 8592-8595. |
| Abstract: | Thera/NO – a small molecule that is activated by hydrogen peroxide to generate nitric oxide (NO) and a fluorescence signal is reported. Using cancer and primary cells, we show that Thera/NO preferentially releases NO in cancer cells, which can trigger DNA damage and cell death in them. The coupled fluorescence signal facilitated tracking the NO release in living cells without collateral consumption of NO. |
| URI: | http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/3210 https://doi.org/10.1039/C7CC08526E |
| ISSN: | 1359-7345 1364-548X |
| Appears in Collections: | JOURNAL ARTICLES |
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