Novel Multi-coded Recognition Motifs for Fully Extended Programmed Molecular Self Assembly

Abstract

A synthetic pathway for the synthesis of multi-coded molecular recognition motifs anticipated to exhibit fully extended programmed molecular self-assembly was developed. These systems may find applications in the development of designer peptides (for e.g. artificial sheets). While synthesizing these motifs, various valuable intermediates were successfully achieved through a series of nucleophilic substitution reactions, which featured pre-organized self-complimentary H-bonding between alternating acceptor (A) and donor (D) sites. During the course of this study, a novel synthetic protocol has also been developed to realize conjugation of aminopyridines with 1,3,5-triazine core.