Please use this identifier to cite or link to this item: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/3568
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dc.contributor.authorKondhalkar, Mrinmayee Ben_US
dc.contributor.authorApte, Kishorien_US
dc.contributor.authorWATVE, MILINDen_US
dc.contributor.authorPaygude, Shubhandgien_US
dc.contributor.authorParab, Pradeepen_US
dc.date.accessioned2019-07-01T06:40:03Z-
dc.date.available2019-07-01T06:40:03Z-
dc.date.issued2017-02en_US
dc.identifier.citationMatters, 11(20),1440.en_US
dc.identifier.issn2297-8240en_US
dc.identifier.urihttp://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/3568-
dc.identifier.urihttps://doi.org/10.19185/matters.201702000001en_US
dc.description.abstractWe examined the action of ricin and related protein abrin on hair follicle (HF) and re-growth of hair. Topical application of ricin in BALB/C and C57BL/6 mice after hair removal by waxing, resulted in sparse and delayed re growth of hair. Histopathological examination revealed hair follicle dystrophy and dose-dependent reduction in the number of hair follicles. Ricin-treated hair follicles showed immediate dystrophic catagen induction and were found to be dystrophic. The characteristic features of ricin-treated hair follicles resembled chemotherapy-induced hair follicle dystrophy such as presence of many ectopic melanin granules, follicular and hair shaft distortion, and irregular diameter of hair bulbs. During in vitro human hair follicle organ culture, ricin- and abrin-treated hair follicles showed inhibition of hair shaft elongation, premature HF regression, and hair follicle dystrophy. During preclinical toxicology studies, ricin was found to be safe for sub-acute dermal test for 90 days for a dose equivalent to the human dose of 160 ?g/kg. Our novel observations propose ricin to be a promising candidate for inhibiting growth of hair follicle by inducing dystrophy without adversely affecting other skin structuresen_US
dc.language.isoenen_US
dc.publisherScience Matters AGen_US
dc.subjectBiologicalen_US
dc.subjectDermal Routeen_US
dc.subjectHirsutismen_US
dc.subjectHair Follicle Dystrophyen_US
dc.subjectFollow-upen_US
dc.subject2017en_US
dc.titleUgly duckling or a swan: Exploring therapeutic potential of ricin for inhibiting unwanted hair growthen_US
dc.typeArticleen_US
dc.contributor.departmentDept. of Biologyen_US
dc.identifier.sourcetitleMattersen_US
dc.publication.originofpublisherForeignen_US
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