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http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/3602| Title: | Design, Synthesis, and Evaluation of Thiol-Activated Sources of Sulfur Dioxide (SO2) as Antimycobacterial Agents |
| Authors: | Malwal, Satish Sriram, Dharmarajan Yogeeswari, Perumal Konkimalla, V. Badireenath CHAKRAPANI, HARINATH Dept. of Chemistry |
| Keywords: | Chemistry 2011 |
| Issue Date: | Nov-2011 |
| Publisher: | American Chemical Society |
| Citation: | The Journal of Medicinal Chemistry, 55(1), 553-557. |
| Abstract: | Here, 2,4-dinitrophenylsulfonamides with tunable cysteine-activated SO2 release profiles with half-lives of SO2 release varying from 2 to 63 min are reported. N-Benzyl-2,4-dinitrobenzenesulfonamide (6), which is prepared in one step from commercial sources, had a potency (MIC = 0.15 μM) of inhibiting Mycobacterium tuberculosis (Mtb) higher than the clinical agent isoniazid (MIC = 0.37 μM). |
| URI: | http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/3602 https://doi.org/10.1021/jm201023g |
| ISSN: | 0022-2623 1520-4804 |
| Appears in Collections: | JOURNAL ARTICLES |
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