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http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/3612| Title: | 4(R/S)-Guanidinylprolyl Collagen Peptides: On-Resin Synthesis, Complexation with Plasmid DNA, and the Role of Peptides in Enhancement of Transfection |
| Authors: | NANDA, MANASWINI GANESH, KRISHNA N. Dept. of Chemistry |
| Keywords: | Chemistry 2012 |
| Issue Date: | Mar-2012 |
| Publisher: | American Chemical Society |
| Citation: | The Journal of Organic Chemistry, 77 (8), 4131-4135. |
| Abstract: | Chimeric collagen peptides containing cationic 4(R/S)-guanidinylproline are synthesized by in situ amidinylation of 4(R/S)-aminoproline residues. These peptides uniquely enhance the transfection efficiency of GFP-encoded plasmid DNA (pRmHa3-GFP) into cells through efficient DNA condensation resulting from nonspecific electrostatic interactions of cationic guanidino groups and localize in subcytoplasmic organelles. |
| URI: | http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/3612 https://doi.org/10.1021/jo300070p |
| ISSN: | 0022-3263 1520-6904 |
| Appears in Collections: | JOURNAL ARTICLES |
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