Please use this identifier to cite or link to this item: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/3647
Full metadata record
DC FieldValueLanguage
dc.contributor.authorKashyap, Smitaen_US
dc.contributor.authorJEGANMOHAN, MASILAMANIen_US
dc.date.accessioned2019-07-23T11:09:21Z
dc.date.available2019-07-23T11:09:21Z
dc.date.issued2012-07en_US
dc.identifier.citationJournal of Physical Chemistry B, 116 (32), 9820-9831.en_US
dc.identifier.issn1520-6106en_US
dc.identifier.issn1520-5207en_US
dc.identifier.urihttp://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/3647-
dc.identifier.urihttps://doi.org/10.1021/jp304121den_US
dc.description.abstractSynthetic macromolecular diblocks sorting into mutivesicular bodies (MVBs) and their fluorophore encapsulation pathways were reported. Renewable resource based diblocks having hydrophobic units and flexible hydrophilic polyethylene glycols (PEG) were custom designed for the above purpose. Single crystal structure was resolved to prove the existence of the strong intermolecular interactions and the formation of unilamellar layer-like self-assemblies. These amphiphilic AB diblocks underwent selective vesicular fission either by outward budding or inward invagination to produce small unilamellar vesicles (SUVs) or MVBs, respectively. Self-organization parameters such as relative volume (νe) and reduced area difference (Δa0) were determined on the basis of theoretical models, and very good correlation with the experimental results was established for the synthetic-MVBs. Pyrene was encapsulated to study the mechanistic aspects of the MVB formations. An unusual nonlinear trend was observed in the pyrene dynamic excimer formation with respect to the sorting of diblock membrane into MVBs. Strong intermolecular interaction was found to be a critical deciding factor in synthetic diblock membranes to facilitate MVBs. The approach demonstrated here opens up new design strategies for biomimicking of MVBs in synthetic macromolecules which are potential vectors for drug delivery.en_US
dc.language.isoenen_US
dc.publisherAmerican Chemical Societyen_US
dc.subjectAmphiphilic Diblocksen_US
dc.subjectMultivesicular Bodiesen_US
dc.subjectFluorophoreen_US
dc.subjectEncapsulation Capabilitiesen_US
dc.subjectSynthetic macromolecularen_US
dc.subject2012en_US
dc.titleAmphiphilic Diblocks Sorting into Multivesicular Bodies and Their Fluorophore Encapsulation Capabilitiesen_US
dc.typeArticleen_US
dc.contributor.departmentDept. of Chemistryen_US
dc.identifier.sourcetitleJournal of Physical Chemistry Ben_US
dc.publication.originofpublisherForeignen_US
Appears in Collections:JOURNAL ARTICLES

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.