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Title: Characterization of biocompatible NiCo2O4 nanoparticles for applications in hyperthermia and drug delivery
Authors: Kale, S. N.
Jadhav, A. D.
Koppikar, S. J.
Kaul-Ghanekar, R.
Dhole, S. D.
Dept. of Chemistry
Keywords: Characterization of biocompatible
NiCo2O4 nanoparticles
Hyperthermia and drug delivery
Superparamagnetic nickel cobaltite
Issue Date: May-2012
Publisher: Elsevier B.V.
Citation: Nanomedicine: Nanotechnology, Biology and Medicine, 8(4), 452-459.
Abstract: Monodispersed, superparamagnetic nickel cobaltite (NCO) nanoparticles were functionalized using mercaptopropionic acid (MPA). MPA conjugates with NCO forming a metal-carboxylate linkage, with the MPA-MPA interaction occurring via formation of disulfide bonds, leaving another carboxyl end free for additional conjugation. The cytotoxicity studies on NCO-MPA show cell viability of ∼100% up to a dosage of 40 μg/mL on SiHa, MCF7, and B16F10 cell lines, and on mouse primary fibroblasts. Time-dependent cell viability studies done for a duration of 72 hours showed the cell lines’ viability up to 80% for dosages as high as 80 μg/mL. Negligible leaching (<5 ppm) of ionic Co or Ni was noted into the delivery medium. Upon subjecting the NCO-MPA dispersion (0.1 mg/mL) to radiofrequency absorption, the nanoparticles were heated to 75°C within 2 minutes, suggesting its promise as a magnetic hyperthermia agent. Furthermore, the amino acid lysine and the drug cephalexin were successfully adducted to the NCO system, suggesting its potential for drug delivery.
ISSN: 1549-9634
Appears in Collections:JOURNAL ARTICLES

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