Please use this identifier to cite or link to this item: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/3803
Full metadata record
DC FieldValueLanguage
dc.contributor.authorHARISH, ROHIT KRISHNANen_US
dc.contributor.authorTENDULKAR, SHWETAen_US
dc.contributor.authorDEIVASIGAMANI, SENTHILKUMARen_US
dc.contributor.authorRatnaparkhi, Anuradhaen_US
dc.contributor.authorRATNAPARKHI, GIRISH S.en_US
dc.date.accessioned2019-08-26T06:52:58Z
dc.date.available2019-08-26T06:52:58Z
dc.date.issued2019-08en_US
dc.identifier.citationFrontiers in Cell and Developmental Biology, 7.en_US
dc.identifier.issn2296-634Xen_US
dc.identifier.urihttp://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/3803-
dc.identifier.urihttps://doi.org/10.3389/fcell.2019.00145en_US
dc.description.abstractMonensin Sensitive 1 (Mon1) is a component of the Mon1:Ccz1 complex that mediates Rab5 to Rab7 conversion in eukaryotic cells by serving as a guanine nucleotide exchange factor for Rab7 during vesicular trafficking. We find that Mon1 activity modulates the complexity of Class IV dendritic arborization (da) neurons during larval development. Loss of Mon1 function leads to an increase in arborization and complexity, while increased expression, leads to reduced arborization. The ability of Mon1 to influence dendritic development is possibly a function of its interactions with Rab family GTPases that are central players in vesicular trafficking. Earlier, these GTPases, specifically Rab1, Rab5, Rab10, and Rab11 have been shown to regulate dendritic arborization. We have conducted genetic epistasis experiments, by modulating the activity of Rab5, Rab7, and Rab11 in da neurons, in Mon1 mutants, and demonstrate that the ability of Mon1 to regulate arborization is possibly due to its effect on the recycling pathway. Dendritic branching is critical for proper connectivity and physiological function of the neuron. An understanding of regulatory elements, such as Mon1, as demonstrated in our study, is essential to understand neuronal function.en_US
dc.language.isoenen_US
dc.publisherFrontiers Media S.A.en_US
dc.subjectFluxen_US
dc.subjectEndocytic recyclingen_US
dc.subjectRab conversionen_US
dc.subjectEpistasisen_US
dc.subjectClass IV neuronen_US
dc.subjectTOC-AUG-2019en_US
dc.subject2019en_US
dc.titleMonensin Sensitive 1 Regulates Dendritic Arborization in Drosophila by Modulating Endocytic Fluxen_US
dc.typeArticleen_US
dc.contributor.departmentDept. of Biologyen_US
dc.identifier.sourcetitleFrontiers in Cell and Developmental Biologyen_US
dc.publication.originofpublisherForeignen_US
Appears in Collections:JOURNAL ARTICLES

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.