2-Methoxyphenyl isocyanate: a chemoselective multitasking reagent for an amine protection/deprotection sequence

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Title:	2-Methoxyphenyl isocyanate: a chemoselective multitasking reagent for an amine protection/deprotection sequence
Authors:	Velappan, Anand Babu Kogatam, Subhashini DATTA, DHRUBAJYOTI Srithar, Rakshantha Nanjappan, Gunasekaran Debnath, Joy Dept. of Chemistry
Keywords:	Solid-Phase Synthesis Palladium-Catalyzed Amination Protecting Groups Fmoc Acids Trifluoroacetylation Strategies Efficient Cleavage Ketones 2019
Issue Date:	Jul-2019
Publisher:	Royal Society of Chemistry
Citation:	Organic Chemistry Frontiers, 6(14), 2360-2364.
Abstract:	Organic amines, in general, are protected through carbamate bond mediated cappings. Herein, we have demonstrated the chemically stable urea linkage suitably employed for protection/deptrotection of amino groups. The stability of the urea linkage under acidic, alkaline and aqueous conditions is an additional advantage for such a protecting group. Therefore the chemoselective nature of 2-methoxyphenyl isocyanate enables its use as a new class of protecting groups which can regenerate free amines after a convenient deprotection step.
URI:	http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/3828 https://doi.org/10.1039/c9qo00293f
ISSN:	2052-4129
Appears in Collections:	JOURNAL ARTICLES

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