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http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/3951| Title: | Isolation and structure elucidation of halymeniaol, a new antimalarial sterol derivative from the red alga Halymenia floresii |
| Authors: | MEESALA, SRINU GURUNG, PRATIMA KARMODIYA, KRISHANPAL Subrayan, Parameswaran WATVE, MILIND Dept. of Biology |
| Keywords: | Algae Sterols NMR & mass spectrometry Natural products Antimalarial activity 2018 |
| Issue Date: | 2018 |
| Publisher: | Taylor & Francis |
| Citation: | Journal of Asian Natural Products Research, 20(4), 391-398. |
| Abstract: | A new mono-hydroxy acetylated sterol derivative: 12β-hydroxy-3β, 15α, 16β-triacetoxy-cholest-5-en-7-one (halymeniaol) (1), and cholesterol (2) were isolated from the marine red alga Halymenia floresii. The structure of the compound 1 (halymeniaol) was established from its spectral data, derived from HRMS/MS and 2D NMR. Compound 1 exhibited growth inhibitory activity against chloroquine-resistant Plasmodium falciparum 3D7 strain with an IC50 of 3.0 μM. |
| URI: | http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/3951 https://doi.org/10.1080/10286020.2017.1342636 |
| ISSN: | 1028-6020 1477-2213 |
| Appears in Collections: | JOURNAL ARTICLES |
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