Please use this identifier to cite or link to this item: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/3971
Title: 1H, 13C and 15N resonance assignment of domain 1 of trans-activation response element (TAR) RNA binding protein isoform 1 (TRBP2) and its comparison with that of isoform 2 (TRBP1)
Authors: PAITHANKAR, HARSHAD
Jadhav, Pankaj V.
Naglekar, Amit S.
Sharma, Shilpy
CHUGH, JEETENDER
Dept. of Biology
Dept. of Chemistry
Keywords: TRBP1
TRBP2 Backbone assignment
RNA binding modes
NMR spectroscopy
2018
Issue Date: Feb-2018
Publisher: Springer Nature
Citation: Biomolecular NMR Assignments, 12(1), 189-194.
Abstract: TAR RNA binding protein (TRBP) is a double-stranded RNA binding protein involved in various biological processes like cell growth, development, death, etc. The protein exists as two isoforms TRBP2 and TRBP1. TRBP2 contains additional 21 amino acids at its N-terminus, which are proposed to be involved in its membrane localization, when compared to TRBP1. The resonance assignment (19–228) of the double-stranded RNA binding domains (dsRBD 1 and 2) of TRBP2 has been reported earlier. Here, we report 1H, 13C and 15N resonance assignment for dsRBD1 of TRBP2 (1–105) containing the additional N-terminal residues. This assignment will provide deeper insights to understand the effect of these residues on the structure and dynamics of TRBP2 and would therefore help in further elucidating the differences in the role of these isoforms.
URI: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/3971
https://doi.org/10.1007/s12104-018-9807-6
ISSN: 1874-2718
1874-270X
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