Please use this identifier to cite or link to this item: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/403
Title: Neural mechanisms underlying feeding drive
Authors: GHOSE, AURNAB
KANIGANTI, TARUN
Dept. of Biology
20091041
Keywords: 2014
Neural Mechanisms
Feeding Drive
Issue Date: Jun-2014
Abstract: Changes in the brain activity patterns are the neural correlates underlying behavioural flexibility. Previous studies con ducted in our lab oratory have identified CART as a major anorexia inducing agent in zebrafish. CART induces neuronal activity in the medial region of dorsal telencephalon (Dm) by potentiating the NMDA receptor activit y rendering the Dm neurons hyperexcitab le . Herein , we used CART as an entry point and identified the neural circuitries that regulate feeding drive in zebrafish, Danio rerio . We found that the CART and NPY neurons , at discrete sites in hypothalamus and in the ventral telencephalon are the major gluco - responsive neurons in the brain. T hese apparently ener gy sensing neurons project to Dm and seem to modulate the activity of the constituent neurons. Both NPY and CART act through parallel , yet opposing, mechanisms and alter the neuronal activity in Dm leading to a switch - like action between the satiety and hunger states . Each of these state s last over an extended period of time and may be attributed to the biochemical modulation of the neuronal activity. Here, we describe the possible mechanisms , and their neuroanatomical correlates, through which these neuromodulators influence food intake . Sensory modalities like olfaction also play a major role in sensing the energy status and influencing energy acquisition . NPY in the olfactory system seems to mod ulat e the feeding drive in an energy dependent manner . In brief, Dm emerges as an integration centre of CART and NPY mediated interoceptive inputs, whose activity may determine the feeding state.
URI: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/403
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