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http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/4117| Title: | Cobalt-catalyzed cyclization of benzamides with alkynes: a facile route to isoquinolones with hydrogen evolution |
| Authors: | MANOHARAN, RAMASAMY Jeganmohan, Masilamani Dept. of Chemistry |
| Keywords: | N Bond Formation C-H Activation Directed Functionalization Internal Oxidant Annulation Access; Amides Carbonylation Derivatives Olefination TOC-SEP-2019 2018 |
| Issue Date: | Sep-2018 |
| Publisher: | Royal Society of Chemistry |
| Citation: | Organic & Biomolecular Chemistry, 16(37), 8384-8389. |
| Abstract: | The reaction of benzamides with alkynes assisted by an 8-aminoquinoline ligand in the presence of Co(OAc)2·4H2O and pivalic acid under an air atmosphere provided isoquinolone derivatives in good to excellent yields. In this reaction, the active Co(III) species is regenerated by the reaction of Co(I) species with pivalic acid under an air atmosphere with hydrogen evolution. The proposed mechanism was supported by competition experiments, deuterium labelling studies, radical scavenger experiments and kinetic studies. |
| URI: | http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/4117 https://doi.org/10.1039/c8ob01924j |
| ISSN: | 1477-0520 1477-0539 |
| Appears in Collections: | JOURNAL ARTICLES |
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